Edetic acid

CAS No. 60-00-4

Edetic acid( Ethylenediaminetetraacetic acid,EDTA )

Catalog No. M22406 CAS No. 60-00-4

Edetic acid is a chelating agent commonly used in protein purification, both to eliminate contaminating divalent cations and to inhibit protease activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
500MG 51 In Stock
1G 70 In Stock

Biological Information

  • Product Name
    Edetic acid
  • Note
    Research use only, not for human use.
  • Brief Description
    Edetic acid is a chelating agent commonly used in protein purification, both to eliminate contaminating divalent cations and to inhibit protease activity.
  • Description
    Edetic acid is a chelating agent commonly used in protein purification, both to eliminate contaminating divalent cations and to inhibit protease activity.
  • In Vitro
    ——
  • In Vivo
    Animal Model: Male Wistar rat model of cirrhosis induced by CCl4Dosage:60 mg/kg, 120 mg/kg, 240 mg/kg Administration: Intraperitoneal injection (i.p.); Three times per week for 3 weeks (during this period, CCl4 administration continued). After CCl4 and mineral oil mixture treatment (200 μL/mouse; i.p.; Three times per week for eight weeks).Result:Kept kept all the rats alive at the 60 mg/kg dose, but died at 120 and 240 mg/kg.Reduced fibrosis of the liver in surviving rats (20%).Animal Model:Male Wistar rat model of cirrhosis induced by CCl Dosage:60 mg/kg Administration:Intraperitoneal injection (i.p.); Three times per week for 11 weeks. EDTA and CCl4 were administered during 11 weeks, three times per week on alternate days). Intraperitoneal injection (i.p.); Three times per week. After CCl4 treatment (i.p.; Three times per week for eight weeks) (Therapeutic EDTA group: EDTA and CCl4 were administered for 3 weeks, three times per week on alternate days).Result:Increased sod activity by 50% in the preventive EDTA group. (Compared with untreated EDTA group)Increased Cp activity in the preventive EDTA (30%) and therapeutic EDTA (20%) groups. (Compared with the fibrotic group).Decreased mRNA expression of the pro-inflammatory molecule (TNF-α and LI-6) and the profibrogenic molecules (TGF-β and αCOLI) in both the prevention and treatment groups.
  • Synonyms
    Ethylenediaminetetraacetic acid,EDTA
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    60-00-4
  • Formula Weight
    292.24
  • Molecular Formula
    C10H16N2O8
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?0.1 M NaOH : 6.67 mg/mL (22.8)
  • SMILES
    OC(=O)CN(CCN(CC(O)=O)CC(O)=O)CC(O)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.D, Lebeau, P.E, et al. Direct analysis of ethylenediaminetetraacetic acid (EDTA) on concrete by reactive-desorption electrospray ionization mass spectrometry[J]. Talanta, 2015.
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